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00:00:00 – 00:25:17
The video is the second segment of a three-part series focused on understanding the relationship between genetics, specifically the methylation cycle, and ADHD. The primary gene discussed is MTHFR, which plays a key role in converting folate for DNA synthesis and repair, and its variants (c677t and a1298c) impact enzyme activity levels. Additionally, the speaker highlights the overall importance of the methylation cycle in regulating gene expression, detoxification, neurotransmitter production, and mental wellness.
The discussion also includes other significant genes such as SHMT1, MTRR, MTR, and FUT2, each contributing differently to the methylation process and ADHD symptoms. SHMT1 affects the conversion of serine to glycine, MTRR and MTR are involved in homocysteine to methionine conversion necessary for SAM-e production, while FUT2 is crucial for B12 absorption.
Practical advice includes avoiding synthetic folic acid in foods, understanding personal genetic variations through testing, and considering appropriate supplements like folinic acid or non-methylated B12 forms for those with specific genetic mutations. The ultimate goal is to offer personalized strategies for better managing ADHD symptoms, emphasizing the comprehensive understanding of genetics and methylation rather than focusing on single gene mutations. The video encourages seeking personalized medical advice and staying informed through available resources.
00:00:00
In this part of the video, the host introduces the second segment of a three-part series exploring the relationship between genetics and ADHD. The focus is on the MTHFR gene, its impact on ADHD and autism, and its significant role in the methylation cycle. The host emphasizes the importance of a comprehensive understanding of the entire methylation cycle rather than looking at MTHFR in isolation. The video aims to empower parents by providing in-depth knowledge on MTHFR and its implications for effectively managing ADHD. The importance of the methylation process is also highlighted, explaining its role in adding methyl groups to molecules like DNA and toxins.
00:03:00
In this segment of the video, the speaker explains the importance of methylation in the context of ADHD. Methylation significantly impacts gene expression by turning genes on or off and plays a crucial role in regulating various bodily functions. The methylation cycle is essential for removing environmental toxins, producing neurotransmitters like serotonin and melatonin, and maintaining mental wellness, focus, and behavior. Additionally, a significant portion of DNA needs to be methylated for proper function, impacting long-term memory formation, blood vessel repair, and neural development. Even if a few genes in the methylation cycle are suboptimal, the overall efficiency of the cycle is what matters most.
00:06:00
In this part of the video, the speaker discusses the importance of not focusing solely on one gene mutation but rather considering the overall picture, particularly in the context of methylation. The first gene explored is MTHFR, often called the poster child of the methylation cycle due to its connection with autism prevalence. The enzyme MTHFR, crucial for the methylation process, converts 510 methylene tetrahydrofolate into 5-methyl tetrahydrofolate, the active form of folate, essential for DNA synthesis and repair. Genetic variations in MTHFR can affect enzyme efficiency, impacting overall methylation and bodily processes. The two specific mutations in MTHFR examined are c677t and a1298c, whose effects are cumulative, influencing MTHFR function differently depending on the combination of these mutations.
00:09:00
In this part of the video, the speaker explains how different combinations of mutations in the MTHFR gene impact enzyme activity levels. For instance, two mutations in c677t result in only 25% activity, while one mutation each in c677t and a1298c results in 48% activity. Most individuals tested fall between 66% to 83% activity, and 100% activity is very rare. The speaker emphasizes the importance of avoiding fortified foods with synthetic folic acid if you have an MTHFR mutation, as excess folic acid can lead to health issues like cognitive decline and increased cancer cell growth. Two main takeaways are highlighted: avoid synthetic folic acid in fortified foods, and consider cumulative effects of mutations to determine enzyme activity. The speaker also mentions they will provide a table in the show notes to help viewers understand their specific genetic enzyme activity levels.
00:12:00
In this part of the video, the speaker discusses the potential issues with using methyl folate (5-MTHF) supplements, particularly for individuals with certain gene mutations. The advice is not to rush into taking this supplement without considering the entire methylation cycle. Other genes, such as SHMT1, MTRR, MTR, and FUT2, also play significant roles in this cycle. Specifically, SHMT1 is highlighted for its function in converting the amino acid serine into glycine, a neurotransmitter important for brain function and potentially affecting ADHD symptoms. For individuals with mutations in the SHMT1 gene, folinic acid might be a better supplement option than methyl folate. Both folinic acid and methyl folate are forms of vitamin B9 essential for various bodily processes, including DNA synthesis and amino acid conversion.
00:15:00
In this part of the video, the speaker discusses the role of the SHMT1 gene in converting serine to glycine and how a mutation can affect this process. Folinic acid, a more flexible form of vitamin B9, is recommended over methyl folate for those with an SHMT1 mutation because it can be more effectively converted by the body, thereby potentially helping to balance neurotransmitters and manage ADHD symptoms. The segment then shifts focus to the MTRR gene, which is crucial for converting homocysteine to methionine. Methionine is necessary for producing SAM-e, a molecule important for making brain chemicals, gene regulation, and detoxification. Malfunctioning MTRR can lead to elevated homocysteine levels, contributing to inflammation and worsening ADHD symptoms. Understanding these genes offers insights into managing ADHD symptoms more effectively.
00:18:00
In this part of the video, the discussion focuses on the MTR gene and its role in turning homocysteine into methionine, similar to the MTRR gene but with unique considerations involving vitamin B12. A mutation in the MTR gene can result in difficulties handling methylated B12, leading to over-methylation, inflammation, and exacerbated ADHD symptoms. The recommended solution is using a non-methylated form of B12 called adenosylcobalamin, which supports the MTR enzyme without the risk of over-methylation.
Additionally, the video transitions to discussing the FUT2 gene, which is crucial for the absorption of vitamin B12. A mutation in the FUT2 gene can impair B12 absorption, impacting the body’s methylation process. Ensuring efficient absorption of B12 is essential since B12 is a key component of the methylation process that fine-tunes body functions.
00:21:00
In this segment, the discussion is centered around the role of the FUT2 gene mutation in exacerbating ADHD symptoms and its impact on B12 absorption. The speaker explains that a FUT2 mutation can create a bottleneck in the methylation process due to inefficient B12 passage. To address this, it’s essential to determine the need for B12 through blood tests for B12 and homocysteine levels. If supplementation is necessary, they recommend using liposomal B12 forms (either lozenges, liquid, or IV) to bypass gut absorption issues associated with the FUT2 mutation. This ensures proper absorption and effectiveness of B12. The segment concludes by highlighting the importance of understanding various genes (SHMT1, MTRR, MTR, and FUT2) for creating a personalized ADHD management plan.
00:24:00
In this segment, the speaker emphasizes the importance of understanding ADHD for making better choices for oneself or one’s child. They encourage viewers to seek personalized advice from health practitioners and to share the helpful episode with others. They remind the audience to subscribe for more tips and strategies on managing ADHD and highlight that this is the second part of a three-part series, urging viewers to tune in next week for the final part. Additionally, the speaker directs listeners to their website and social media for more information on natural ADHD strategies.